As a preclinical CRO with 15+ years of experience supporting complex R&D programs for a wide array of startup, biotech and large pharmaceutical companies, Powered Research delivers tightly controlled, end-to-end studies designed for rapid decisions based on quality data generation.
Our expert Leadership Team share decades of drug development experience.
We offer a full suite of services for evaluating potential cancer therapeutics, from experimental design and in vivo tumor modeling to extensive endpoint analyses.
Our non-GLP preclinical oncology CRO services support early-stage drug discovery with integrated pharmacology, PK/PD modeling, and biomarker-driven strategies to accelerate lead optimization and candidate selection. We have deep expertise in immuno-oncology, including evaluation of checkpoint inhibitors, combination therapies, and immune-modulating agents using advanced syngeneic, humanized, and xenograft tumor models.
Our capabilities span a range of clinically relevant cancer types, including breast, lung, colorectal, and bladder malignancies, enabling translational oncology studies that generate actionable efficacy, pharmacokinetic, and pharmacodynamic data.
Powered Research partners with biotech and pharmaceutical companies seeking flexible, high-quality non-GLP oncology studies to de-risk pipelines and support IND-enabling research.
Our Capabilities:
Rodent housing in a 20,000 sq ft multi-species vivarium staffed by highly trained technicians and veterinarians
Human and murine cell culture in a modern 2,000 sq ft laboratory
Flexible and customized flow panels for deep immune profiling with our 5-laser Cytek® Aurora spectral cytometer
Study design
Cell culture and tumor implantation
Test agent dosing via any route
Timed samplings and necropsy
Endpoint Data:
Tumor volume and body weight
Weekly data updates
MTDs and dose-range finding
PK/PD
Immunophenotyping by flow cytometry
Cytokine analysis
H&E staining
Immunohistochemistry
Immunofluorescence
Image analysis
Subcutaneous CT26 colon carcinoma growth inhibition after immune checkpoint inhibitor treatment
Tumor Immunophenotyping and Cytokine Analysis
We offer a comprehensive suite of standard and custom tumor immunophenotyping panels and cytokine arrays. Our scientists excel in piloting and optimizing new techniques and processes with flexibility, speed, and resourcefulness, ensuring reproducibility and tailored solutions to advance your preclinical R&D programs.
Services Available:
Tissue Processing:
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Cell/organ harvest and fixation
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Cell isolation
Flow Cytometry
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Full-spectrum Cytek® Aurora flow cytometer with automated sample loader
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Immunophenotyping of a variety of tissues (e.g., blood, spleen, tumor)
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Standard and custom panel designs with 18+ color options
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Cytokine analysis of serum/plasma and tumor lysates
Tumor T Lymphocyte Populations
Reproducible Immunophenotyping Results Across Experiments
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CT26 tumor cytokine analysis by cytometric bead array
In-House In Vitro Services
We offer a full suite of in-house services for assessment of novel cancer therapeutics. Our scientists pilot and optimize new techniques and processes with flexibility, speed, and resourcefulness to advance your preclinical R&D programs.
Services Available:
Front to Back Tissue Processing:
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Cell/organ harvest and fixation
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Cell isolation
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Paraffin embedding and cryopreservation
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Sectioning and staining
Flow Cytometry
Histopathology
Immunohistochemistry
Immunofluorescence
RNAscope® in situ hybridization
Fluorescence microscopy
Light microscopy
Fluorescence live imaging
Image analysis and quantification
qPCR
ELISA
Western blotting
Cell culture (BSL2)
Custom designed assays
3D Cell Culture
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Brightfield In Culture
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H&E
Tumor Microscopy
Tissue Histology
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Immunohistochemistry & Immunofluorescence
CD3 | CD31 | F4/80 | Isolectin I-B4 | CD4 | CD8 | CD68 | Ki67 | PD-L1 | And many more!
For a detailed listing of our preclinical oncology capabilities, view our brochure:
Explore our FAQs for more information.
Our Services
Powered Research is well known for rapid study turnaround, and our scientific experts allow for timely study scheduling and execution.
Our staff has extensive expertise in the design and development of non-GLP preclinical data packages, including tolerability and pharmacology models, drug distribution studies, and custom experimental designs.
AAALAC Accredited
Certified Excellence
Flexibility
Use our internal protocols or work with us to design your own.
Scalability
Our clients include small startups, large pharma companies, and biotech companies.
70 Domain Experts
A committed team of scientists, veterinarians, and technicians.
Satisfaction
97% of our clients place a second study with us in the first 6 months.
