Safety, Tolerability, & Toxicology
Whether you are developing a new chemical entity, reformulating a marketed product, or advancing a novel drug delivery system, early evaluation of ocular safety, tolerability, and toxicology is essential prior to definitive GLP studies.
Powered Research provides non-GLP preclinical ophthalmology CRO services, with validated protocols for assessing ocular toxicology and pharmacology, generating critical safety data to support ocular drug development.
Our ocular tolerability and safety studies are conducted in rodents, rabbits, and swine across multiple routes of administration and include standard and advanced toxicology endpoints. All ophthalmic exams are performed by a board-certified veterinary ophthalmologist, ensuring high-quality, reliable, and translational safety data.
All-in-One Service:
Study design
Cell culture and implant
Test agent dosing via any route
Timed samplings and necropsy
Fully outfitted in vitro lab
Histology core
Routes of Administration:
Subcutaneous
Intracranial
Intrathecal
Intravenous
Oral
Our Capabilities:
Rodent housing in a 20,000 sq ft multi-species vivarium staffed by highly trained technicians and veterinarians
Flexible and customized flow panels for deep immune profiling with our 5-laser Cytek® Aurora spectral cytometer​
Murine and human cell lines available upon request
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Expansion, banking, injection, model development, profiling
Ocular:
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Intravitreal
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Subretinal
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Suprachoroidal
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Intraconjunctival
Endpoints Include
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Clinical Observations: Cageside and detailed observations
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Physiological Measurements: Body weight, food consumption
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Slit-lamp biomicroscopy with SPOTS or Hackett-McDonald scoring
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Indirect ophthalmoscopy conducted by a Board-Certified Veterinary Ophthalmologist
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High-resolution imaging
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Tonometry, Pupillometry, Pachymetry
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Electrophysiology (ERG, OKT)
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Fluorescein angiography
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Optical coherence tomography
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Pharmacokinetics: Systemic (plasma, serum)
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Pathology: Necropsy with macroscopic observations, ocular histopathology
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Immunohistochemistry/Immunofluorescence
Our Services
Powered Research is well known for rapid study turnaround, and our scientific experts allow for timely study scheduling and execution.
Our staff has extensive expertise in the design and development of non-GLP preclinical data packages, including tolerability and pharmacology models, drug distribution studies, and custom experimental designs.
AAALAC Accredited
Certified Excellence
Flexibility
Use our internal protocols or work with us to design your own.
Scalability
Our clients include small startups, large pharma companies, and biotech companies.
70 Domain Experts
A committed team of scientists, veterinarians, and technicians.
Satisfaction
97% of our clients place a second study with us in the first 6 months.
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