Biodistribution for
Gene & Cell Therapy
Gene and cell therapies represent transformative approaches for treating ophthalmic diseases, requiring specialized preclinical evaluation of biodistribution, safety, and efficacy to ensure successful translation.
These advanced modalities demand precise characterization of ocular tissue targeting and vector distribution. Powered Research provides biodistribution studies for gene and cell therapies across multiple routes of administration, leveraging our expertise as a non-GLP ophthalmology CRO.
Cell Therapy
Our team is equipped to evaluate novel cell therapy strategies in ophthalmology and beyond. We specialize in the precise delivery of cell-based materials and detailed analysis of viability and efficacy in your experimental model.
Ocular Cell Therapy Delivery:
Injection sites:
• Subretinal
• Intravitreal
• Intracameral
Our Capabilities:
400-sq-ft cell culture and flow cytometry room
Trained scientists to handle cell culture and preparation prior to dosing
Exposure to a variety of formulations, including hydrogels and ECM grafts
Brightfield and fluorescence imaging
Common Readouts:
Pre- and post-dose cell counts
Optical coherence tomography (OCT)
TUNEL assays (cell viability)
Immunohistochemistry
Brightfield (cells)
Cornea IHC
Fluorescent (cells)
TUNEL
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Endpoints can include: slit-lamp biomicroscopy and indirect ophthalmoscopy, high-resolution fundus imaging, tonometry, pachymetry, pupilometry, fluorescein angiography, optical coherence tomography (OCT), electroretinography, flat mounts, immunofluorescence, TUNEL assays, in situ hybridization and histopathology.
Gene Therapy
We offer services for evaluating novel gene therapy techniques. Our approach includes precise vector delivery and deep characterization of transgene expression and efficacy in your experimental model.
Ocular Gene Therapy Delivery:
Injection sites:
• Subretinal
• Suprachoroidal
• Intravitreal
• Intracameral
• Subconjunctival/Periocular
Ocular Imaging Capabilities:
IVIS Lumina LT (Perkin Elmer)
HRA-OCT Spectralis (Heidelberg Engineering)
Fluorescence microscopy
HRT-3
Digital image analysis
Micron III and X (Phoenix Laboratories)
In Vivo GFP Imaging
Luciferase IHC
GFP/RBPMS IHC
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In Situ Hybridization
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Endpoints can include: slit-lamp biomicroscopy and indirect ophthalmoscopy, high-resolution fundus imaging, tonometry, pachymetry, pupilometry, fluorescein angiography, optical coherence tomography (OCT), electroretinography, flat mounts, immunofluorescence, in situ hybridization and histopathology.
Our Services
Powered Research is well known for rapid study turnaround, and our scientific experts allow for timely study scheduling and execution.
Our staff has extensive expertise in the design and development of non-GLP preclinical data packages, including tolerability and pharmacology models, drug distribution studies, and custom experimental designs.
AAALAC Accredited
Certified Excellence
Flexibility
Use our internal protocols or work with us to design your own.
Scalability
Our clients include small startups, large pharma companies, and biotech companies.
70 Domain Experts
A committed team of scientists, veterinarians, and technicians.
Satisfaction
97% of our clients place a second study with us in the first 6 months.
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