Powered Research supports a comprehensive suite of preclinical ophthalmology disease models to evaluate drugs, biologics, devices, and other interventions for ocular drug development.
As a specialized ophthalmology CRO for early discovery, all ophthalmic examinations are conducted by a board-certified veterinary ophthalmologist, ensuring credible, high-quality, and translational data for ocular pharmacology studies.
Our capabilities include advanced ocular imaging and functional endpoints to enable robust pharmacology and efficacy assessments, including:
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High-resolution retinal imaging
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Pupillometry
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Pachymetry
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Electroretinography (ERG)
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Slit-lamp biomicroscopy
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Intraocular pressure (IOP) measurements
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Optokinetic tracking (OKT)
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Fluorescein angiography
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Optical coherence tomography (OCT)
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3D confocal laser-scanning microscopy
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Bright-field and fluorescence retinal imaging
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Pharmacokinetics
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Ocular histology
We are a USDA-approved and AAALAC-accredited preclinical research facility supporting multiple species and a wide range of indications, including wet AMD, dry AMD, glaucoma, corneal diseases, ocular inflammation, and mouse models of retinal degeneration, with additional custom ophthalmology models available upon request. Our facility also includes 7,000 square feet of dedicated wet-lab space to support flexible study design and efficient execution.
An example of one of our models:
Oxygen-Induced Retinopathy (OIR) Model in Mouse
We offer a robust and reproducible preclinical model of OIR in mice.
OIR Model Advantages
Robust framework for evaluating inhibition of pathological neovascularization
Quantitative assessment through evaluation of signal intensity from flat-mount images
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Conducive to transgenic studies
Isolectin IB4
Percent Retinal Area
Vehicle
Aflibercept
Treatment
Endpoints can include (but are not limited to): slit-lamp biomicroscopy and indirect ophthalmoscopy,high-resolution fundus imaging, tonometry, pachymetry, pupilometry, fluorescein angiography, optical coherence tomography, electroretinography, flat mounts, immunohistochemistry, and histopathology.
An example of our technologies:
Laser Speckle Flowgraphy
Laser Speckle Flowgraphy can visualize and measure the distribution of blood flow in the retina by observing the variations in blood flow synchronized with the heartbeat. Here we offer an overview to support the development of therapies in the rabbit model.
Typical Study Design
Blood flow
Dutch-belted rabbits
Induction with ET-1 (one eye only)
Most measurements in one day (4-6 animals/day)
Lead time ~4 weeks to Day 1 procedures
Mean blur rate (MBR) is derived from a series of images and describes flow. It is proportional to the mean velocity of moving blood cells modulated by tissue environment.
The measured IC50 of ET-1 was determined to be 0.00305 µg in 50 µL injections.
Explore our FAQs for more information.
Correlation Between Nerve Density and Corneal Sensitivity in Two Rabbit Strains
Artificial Intelligence to Quantify Leakage of Neovascular Tufts from Fundus Imaging
Our Services
Powered Research is well known for rapid study turnaround, and our scientific experts allow for timely study scheduling and execution.
Our staff has extensive expertise in the design and development of non-GLP preclinical data packages, including tolerability and pharmacology models, drug distribution studies, and custom experimental designs.
AAALAC Accredited
Certified Excellence
Flexibility
Use our internal protocols or work with us to design your own.
Scalability
Our clients include small startups, large pharma companies, and biotech companies.
70 Domain Experts
A committed team of scientists, veterinarians, and technicians.
Satisfaction
97% of our clients place a second study with us within the first six months.
