Brain Cancer
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, requiring highly specialized models that accurately recapitulate tumor biology, invasiveness, and CNS constraints.
Powered Research performs preclinical studies using human brain cancer PDX and CDX tumor cells in surgical implantation, dosing, monitoring and comprehensive endpoint analysis under one experienced team. This unified approach ensures consistent execution, rapid turnaround, and high-quality, decision-ready datasets.
We develop and evaluate GBM therapeutics using clinically relevant in vivo models, including stereotactic intracranial and subcutaneous implantation techniques.
These models are supported by robust in vitro platforms (monolayer, spheroids, neurospheres) and flexible dosing routes (intracranial, intravenous, intraperitoneal, intrathecal), enabling tailored study designs aligned with your therapeutic strategy.
Our Capabilities:
Rodent housing in a 20,000 sq ft multispecies vivarium staffed by highly trained technicians and veterinarians
Human and murine cell culture in a modern 2,000 sq ft laboratory
Flexible and customized flow panels for deep immune profiling with our 5-laser Cytek® Aurora spectral cytometer
Cell Culture Capabilities:
Monolayer
Spheroids
Neurospheres
Dose Routes:
Intracranial
Subcutaneous
Intravitreal
Endpoint Data:
In-House In Vitro Services
-
Histopathology
-
Immunohistochemistry
In-life Assessments
-
Flow Cytometry
-
qPCR
Neurosphere
Stereotactic Rig
Subcutaneous U87MG
Intracranial U87MG
-
IVISTM
We offer a comprehensive suite of services, including custom 3D culture modeling to advance your pre-clinical R&D programs. Our scientists excel at piloting and optimizing new techniques and processes with flexibility, speed, and resourcefulness, providing tailored solutions for your cancer therapeutics.
Generating Spheroids and Neurospheres: A Rapid and Reproducible Approach​
3D Cellular Models
Vital for studying cell-cell interactions, drug response, and development in physiologically relevant environments.
Closely mimics in-vivo microenvironment.
Spheroids replicate features observed in solid tumors including nutrient and oxygen gradients.
Neurospheres provide a more physiologically relevant model with further differentiated neural cells.
Overview:
Cell types: LNCap, U87, etc.
Culture duration: 7 - 10 days
Fast and consentient formation of 3D cellular models.
Highly reproducible and scalable
Compatible with downstream analysis(screening. Immunostaining. In vitro-applications).
U87 Neurosphere Growth Over Time
Staining of U87 Neurosphere at Day 7
Comparative Analysis of Therapeutic Responses and Stem Cell Marker Expression in Glioblastoma Neurospheres Versus Monolayer Cultures Using Imaging, Cytotoxicity Assays, & Flow Cytometry.
Biodistribution Analysis of Lutetium-177 Radiopharmaceuticals in Mammary, Prostate, & Glioblastoma Models Using Alpha-SPECT Mini and Gamma Counting.
Advance your glioblastoma program with translationally relevant models and integrated data.
Contact Powered Research to design your next brain cancer preclinical study.