Uveitis
Uveitis encompasses a heterogeneous group of intraocular inflammatory diseases affecting the uveal tract and remains a major cause of preventable vision loss.
Developing preclinical uveitis models for ocular drug development is challenging due to complex immune mechanisms, disease heterogeneity, and limited replication of human pathology in animals.
These challenges can be addressed through validated in vivo models, advanced imaging endpoints, and integration of human immunology data, enabling predictive ocular pharmacology and improved clinical translation.
Experimental Auto-Immune Uveitis
Experimental Autoimmune Uveitis (EAU) is a well-established, consistent animal model in rodents, rabbits, and pigs used to study the mechanisms of autoimmune uveitis, a form of intraocular inflammation that affects the uvea.
Endotoxin-Induced Uveitis
Endotoxin-Induced Uveitis (EIU) is an experimental model used to study acute anterior uveitis and the inflammatory response in the eye. This model is primarily induced in rodents and rabbits, by administering endotoxins, particularly lipopolysaccharides (LPS).
TNF-Induced Uveitis
TNF-Induced Uveitis (TIU) is an experimental model used to study the role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of uveitis, particularly anterior uveitis. TNF-α is a pro-inflammatory cytokine produced by various immune cells, including macrophages and T cells, and plays a central role in the inflammatory response seen in autoimmune and infectious uveitis in humans. Our team of experts has developed reproducible models with consistent results in rodents.
Mycobacterium Tuberculosis-Induced Uveitis
Mycobacterium tuberculosis-induced uveitis refers to uveitis caused by infection with Mycobacterium tuberculosis, the bacterium responsible for tuberculosis (TB). TB uveitis can manifest in various forms depending on the location and severity of the infection within the eye. Our team of experts has developed reproducible models with consistent results in rodents.