Ocular Inflammation
Ocular inflammation encompasses a range of anterior and posterior segment inflammatory conditions that significantly impact vision and are key targets in ocular drug development and ocular pharmacology.
However, preclinical ocular inflammation models present translational challenges, including complex immune responses and variability across species.
These challenges can be addressed using well-characterized in vivo models, multi-species validation, and quantitative imaging endpoints, enabling robust pharmacodynamic assessment and improved clinical translation of anti-inflammatory therapeutics.
Surgically Induced Ocular Inflammation
Surgically induced ocular inflammation refers to inflammation in the eye resulting from various types of ocular surgeries. This inflammation can occur as a natural part of the healing process or as a complication related to the surgery itself.
Phacoemulsification Surgery
Phacoemulsification surgery is a modern technique used for cataract removal, which involves emulsifying the cloudy lens and aspirating it from the eye. This procedure can induce inflammation, and our models are used to evaluate the efficacy of test articles in managing post-surgical inflammation.
Ocular Pain
Corneal Transplantation
In this surgical procedure, a damaged or diseased cornea (the transparent, front part of the eye that covers the iris and pupil) is replaced with healthy corneal tissue from a donor. This procedure is typically performed to improve visual acuity or relieve pain in cases where the cornea has become damaged due to injury, infection, or diseases like keratoconus.
Infectious Keratitis
Infectious keratitis is a serious and potentially sight-threatening condition characterized by inflammation of the cornea due to an infection. It can be caused by bacteria, viruses, fungi, or parasites. Common causes and risk factors include bacterial, viral, fungal, or parasitic infections as well as predisposing conditions such as corneal epithelial defects, dry eye disease, or an immunocompromised state.