Glaucoma Models of Neuroprotection
Glaucoma is one of the leading causes of irreversible blindness worldwide. It is a progressive optic neuropathy characterized by retinal ganglion cell loss and optic nerve degeneration, often associated with elevated intraocular pressure (IOP).
Developing preclinical glaucoma models for ocular drug development remains challenging due to the multifactorial nature of the disease and difficulty replicating chronic neurodegeneration and IOP dynamics in vivo.
These challenges can be addressed through validated in vivo models of ocular hypertension and neuroprotection, combined with quantitative endpoints, enabling predictive ocular pharmacology and improved clinical translation.
N-Methyl D-Aspartate-Induced Excitotoxicity
The N-methyl D-aspartate-induced retinal degeneration model is used to evaluate the efficacy of test articles preventing degeneration of retinal ganglion cells. Our team of experts has developed reproducible models with consistent results in mice.
Optic Nerve Crush
The optic nerve crush retinal degeneration model is used to evaluate the efficacy of test articles preventing degeneration of retinal ganglion cells and neuronal axons. Our team of experts has developed reproducible models with consistent results in mice.
MIGS
Minimally Invasive Glaucoma Surgery. These are a group of surgical procedures designed to reduce intraocular pressure (IOP) in patients with glaucoma, with the goal of preventing further optic nerve damage. MIGS procedures are considered safer and less invasive than traditional glaucoma surgeries, such as trabeculectomy or tube shunt surgery.
Glaucoma: Ocular Hypertension
Glaucoma is a progressive eye disease that leads to vision loss by causing damage to the optic nerve, and ocular hypertension is a contributing factor in this blinding disease.
Silicone Oil Ocular Hypertension
The silicone oil model of ocular hypertension resulting in retinal degeneration is used to evaluate the efficacy of test articles preventing retinal degeneration. Our team of experts has developed reproducible models with consistent results in mice.
Glaucoma Normotensive Models
In naive, normotensive models, test articles and devices can be evaluated for efficacy by measuring a change in intraocular pressure compared to baseline. Our team of experts has developed reproducible models with consistent results in mice, rats, rabbits, and swine.