PHARMACOLOGY

As a specialized leader in the development of ocular pharmacology models, Powered Research can help you to assess the efficacy of your drug product or device candidates. Pharmacology models can be used to differentiate between formulations, active pharmaceutical ingredients, or device iterations, enabling you to choose the most effective product to move forward in development. Powered Research offers more than 15 nonclinical animal efficacy models, each of which is specifically designed to assess the therapeutic efficacy in an ophthalmic disease state, condition, or surgical intervention. Our models are supported by our team of ophthalmic experts, as well as our collection of precise instrumentation, ensuring that our studies are conducted correctly and provide relevant data.

Models include:

• Anterior Chamber Inflammation (paracentesis, corneal incision; rabbit)

• Choroidal Neovascularization (laser; rodent and swine)

• Corneal Wound Healing (alkali, scrape, abrasion; rabbit)

• Experimental Autoimmune and Endotoxin-Induced Uveitis (rat, rabbit)

• Oxygen-Induced Retinopathy (mouse)

• Sodium Iodate-Induced Retinal Degeneration (mouse)

• AAA-Induced Chronic Retinal Neovascularization (rabbit)

• VEGF-Induced Retinal Leakage and Neovascularization (rabbit)

• Phacoemulsification Surgery (rabbit)

• Allergic Conjunctivitis (Guinea pig)

• Normotensive IOP/Glaucoma (rat, rabbit, canine)

• Corneal Transplant (rabbit)

• Dry Eye (mouse, rat)

• DMEK/DSEK Surgical model (rabbit)

• Targeted Drug/Device Delivery (subretinal, IVT, IC, subconjunctival)