Whether you’re developing a new chemical entity, a new formulation of a marketed product, or a new drug delivery system, obtaining an understanding of any potential adverse effects is critical before moving into definitive GLP studies. Powered Research has developed internal protocols for non-GLP assessment of ocular therapeutics, providing key tolerability and safety data.
Our ocular tolerability studies are conducted in rodents, rabbits, swine, or canine with various route of administration, and include standard toxicology endpoints. Additionally, all ophthalmic exams are conducted by a Board-Certified Veterinary Ophthalmologist, lending significant credibility to the results obtained.
Cageside and detailed clinical observations
Body weight, food consumption
Slit lamp biomicroscopy with Hackett-McDonald scoring
Indirect ophthalmoscopy conducted by a Board-Certified Veterinary Ophthalmologist
Tonometry, Pupillometry, Pachymetry
Electrophysiology (ERG, VEP)
Optical coherence tomography
Systemic pharmacokinetics (plasma, serum)
Necropsy with macroscopic observations